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KMID : 0191120110260060824
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Journal of Korean Medical Science
2011 Volume.26 No. 6 p.824 ~ p.828
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Waldenstrom Macroglobulinemia with CD5+ Expression Presented as Cryoglobulinemic Glomerulonephropathy: A Case Report
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Kim You-Lim
Gong Soo-Jung
Hwang Young-Hwan
Joo Jong-Eun
Cho Young-Uk
Lee Jung-Ae
Sung Su-Ah
Lee So-Young
Kim Nae-Yoo
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Abstract
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Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that is important for differential diagnosis of B-cell lymphoproliferative disorders. In WM, various renal diseases and type I cryoglobulinemia are well described separately, but cryoglobulinemic glomerulonephropathy is very rarely reported. A 61-yr-old woman complained of generalized edema, cyanosis of the extremities in cold weather, visual disturbance, and pancytopenia. Bone marrow and renal biopsy showed CD5+ expressing B-cells and cryoglobulinemic glomerulonephropathy. With the diagnosis of WM, she received cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and got complete remission. Here, we report a rare case of WM associated with unusual expression of CD5+ B-lymphocytes and cryoglobulinemic glomerulonephropathy, and emphasize the importance of the clinical features in differentiating CD5+ B-cell lymphoproliferative disorders.
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KEYWORD
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Waldenstrom Macroglobulinemia, CD5+ Lymphoplasmacytic Lymphoma, Cryoglobulinemic Glomerulonephritis
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